Macromolecular synthesis in cells infected by frog virus 3.

نویسندگان

  • D B Willis
  • R Goorha
  • V G Chinchar
چکیده

Previous evidence indicated that frog virus 3 (FV3), an icosahedral DNA virus, replicates exclusively in the cytoplasm. However, data presented here demonstrate that FV3 does not replicate in UV-irradiated or enuleated chicken embryo or BSC-1 cells and that virus-specific DNA synthesis is not initiated in such cells. Primary transcription was not detected in infected enucleated cells. These results demonstrate that a functional nucleus is essential for FV3 replication.

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عنوان ژورنال:
  • Current topics in microbiology and immunology

دوره 116  شماره 

صفحات  -

تاریخ انتشار 1977